mogrol

**Mogrol** is a naturally occurring tetracyclic triterpenoid and the aglycone (non-sugar part) of mogrosides, primarily derived from *Siraitia grosvenorii* (monk fruit), widely used in traditional Chinese medicine and as a natural sweetener source[1][3][5]. Mogrol is formed in the body from mogrosides after oral ingestion by deglycosylation through gastrointestinal enzymes and microbiota[1][3].\nMogrol exhibits multiple pharmacological effects, including:\n- **Activation of AMP-activated protein kinase (AMPK)**, leading to anti-obesity, anti-inflammatory, and anti-diabetes activity\n- **Inhibition of ERK1/2 and STAT3 pathways** (anticancer effect, including inhibition of leukemia and lung cancer cell proliferation)\n- **Inhibition of CREB activation** (reducing adipogenesis)\n- **Neuroprotective effects** (inhibition of NF-κB pathway)\n- **Suppression of osteoclast formation and bone resorption** (potential anti-osteoporosis effect through inhibition of TRAF6 recruitment and MAPK/NF-κB signaling)\n- Potential alleviation of inflammatory conditions (e.g., ulcerative colitis) via inhibition of inflammatory mediator production[3][5][11].

Other names

3α-hydroxymogrol(3S,8S,9R,10R,11R,13R,14S,17R)-17-[(2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,9,13,14-pentamethyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11-diol(10α,24R)-9β-methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol