Drug intelligence / Profile preview

moluodan

Development stage
Phase 2
Lead developer
Handan Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Moluodan is a traditional Chinese patent medicine formulated as a concentrated herbal pill. It is primarily used for the treatment of chronic atrophic gastritis (CAG) and related digestive disorders such as gastralgia, flatulence, anorexia, eructation (belching), and pyrosis (heartburn)[1][3][5]. Clinical studies have shown that Moluodan can improve pathological examination outcomes, gastroscopy findings, and clinical symptoms in patients with CAG. It has also demonstrated efficacy in reversing gastric precancerous lesions—especially dysplasia—and may slow disease progression[1][2]. Mechanistic studies suggest that its therapeutic effects are mediated through modulation of key signaling pathways involved in inflammation and cell proliferation. Specifically, it acts on the tumor necrosis factor (TNF)/PI3K/AKT signaling pathway[3], inhibits the Wnt/β-catenin pathway[8], and downregulates expression of epidermal growth factor (EGF) and c-Myc to repair gastric mucosa and delay progression to precancerous lesions or gastric cancer[8]. The formula contains multiple active compounds derived from traditional Chinese medicinal herbs such as Anemone altaica Fisch., but its precise composition may vary by manufacturer.

Brand names
Moluodan
Other names
MoLuoDanMLDMoluodan concentrated pill
02

Targets

AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TNFA (Tumor necrosis factor alpha (soluble))MYC (MYC proto-oncogene protein)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)

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