Molybdenum Cofactor

The molybdenum cofactor (MoCo) is a vital component required for the proper functioning of molybdenum-dependent enzymes, including sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. In Molybdenum Cofactor Deficiency (MoCD) Type A, the body is unable to synthesize this essential cofactor, leading to the accumulation of neurotoxic metabolites. As a therapeutic agent, the molybdenum cofactor would function as an enzyme cofactor replacement therapy, directly supplying the missing cofactor to restore the activity of these critical enzymes and mitigate the effects of the deficiency. The precursor to the molybdenum cofactor, cyclic pyranopterin monophosphate (cPMP), is administered as fosdenopterin (Nulibry) to enable the body to produce the active molybdenum cofactor.

Other names

{[2-Amino-4-oxo-6,7-di(sulfanyl-κS)-3,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogenato(2-) phosphate}(dioxo)sulfanylmolybdenum