Drug intelligence / Profile preview

mometasone furoate + salicylic acid

Development stage
Unknown
Lead developer
Merck
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Topical
01

Overview

Mometasone furoate + salicylic acid is a fixed-dose topical combination of a potent synthetic corticosteroid (mometasone furoate) and a keratolytic agent (salicylic acid). Mometasone furoate acts as an agonist of the glucocorticoid receptor, inhibiting inflammatory mediators such as prostaglandins and cytokines to reduce redness, swelling, and itching. Salicylic acid breaks down keratin clumps in the skin, removes dead cells through exfoliation, softens plaques or scales (especially in psoriasis), and enhances the penetration of mometasone into affected skin layers. This combination is primarily indicated for dermatological conditions such as psoriasis and eczema where both anti-inflammatory and exfoliating actions are beneficial[1][5][6]. The product is applied topically.

Brand names
CombisorMonsalicElicasal
Other names
mometasone/salicylic acid
02

Targets

GR (Glucocorticoid receptor)COX

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