Drug intelligence / Profile preview

mometasone furoate + sodium fusidate

Development stage
Preclinical
Lead developer
Vanan Pharma
Modality
Small Molecules
Administration
Topical
01

Overview

Mometasone furoate + sodium fusidate is a topical combination therapy developed by Vanan Pharma for the treatment of inflammatory skin disorders complicated by bacterial infection. Mometasone furoate is a potent synthetic corticosteroid that exerts anti-inflammatory, antipruritic, and vasoconstrictive effects by binding to the glucocorticoid receptor, thereby modulating gene expression to reduce the production of inflammatory mediators. Sodium fusidate is a bacteriostatic antibiotic that inhibits bacterial protein synthesis by targeting elongation factor G (EF-G), preventing its release from the ribosome-GDP complex and thus halting the translocation step of translation. This combination is formulated as a topical cream to provide simultaneous relief from inflammation and treatment of susceptible bacterial infections, such as those caused by *Staphylococcus aureus*.

Other names
Mometasone Furoate, Sodium Fusidate
02

Targets

GR (Glucocorticoid receptor)EF-G (Elongation factor G 1, mitochondrial)

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