momordica charantia-derived extracellular vesicles

Momordica charantia-derived extracellular vesicles (MCEVs) are nanoscale vesicles isolated from the plant Momordica charantia (bitter melon), a food and medicinal plant known for its antioxidant and anti-inflammatory properties. These plant-derived extracellular vesicles have demonstrated significant antioxidant activity in vitro and in vivo. Mechanistically, MCEVs act as free radical scavengers, reducing oxidative stress by lowering reactive oxygen species (ROS) levels and restoring mitochondrial function. They also modulate signaling pathways related to cell survival and inflammation—such as increasing p-AKT/AKT and p-ERK/ERK ratios—and promote cell proliferation while suppressing apoptosis. Preclinical studies show that MCEVs can protect against radiation-induced heart disease by mitigating myocardial injury and fibrosis, as well as restore colon health in models of ulcerative colitis through regulation of oxidative damage and inflammatory factors[1][2]. These findings suggest potential applications for MCEVs both as therapeutic agents for diseases involving oxidative stress or inflammation (e.g., cardiovascular injury, ulcerative colitis) and as drug delivery vectors.

Other names

MCEVsMCELNsMomordica charantia EVsMomordica charantia nanovesicles