monoamine oxidase A K305M adenovirus

The monoamine oxidase A K305M adenovirus is a research-grade gene therapy tool consisting of an adenoviral vector that delivers a mutant variant of the human monoamine oxidase A (MAO-A) enzyme. In this variant, the lysine residue at position 305 is replaced by methionine (K305M). This specific mutation renders the enzyme unable to use oxygen as an electron acceptor for reoxidation, thereby preventing the generation of reactive oxygen species (ROS), specifically hydrogen peroxide (H2O2), while maintaining some catalytic turnover through alternative electron acceptors. It is primarily used in academic research to investigate the role of MAO-A-derived oxidative stress in conditions such as age-related cardiovascular disease and bladder cancer metabolic reprogramming.

Other names

MAO-A K305M mutant constructK305M adenovirusK-305M adenovirusK 305M adenovirus