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monophosphoryl lipid A
- Development stage
- Unknown
- Lead developer
- Corixa
- Administration
- Intramuscular, Subcutaneous
01
Overview
Monophosphoryl lipid A is a detoxified derivative of the endotoxin lipopolysaccharide (LPS), specifically derived from Salmonella minnesota R595 LPS by chemical modification[2][4]. It acts as a non-toxic agonist of Toll-like receptor 4 (TLR4), stimulating the innate immune system and enhancing adaptive immune responses. Monophosphoryl lipid A is primarily used as an adjuvant in vaccines, where it boosts immunogenicity while minimizing pro-inflammatory toxicity compared to native LPS[2][8]. It has been incorporated into several licensed vaccine adjuvant systems, such as AS01 and AS04, and is used in both prophylactic and therapeutic vaccines for infectious diseases and cancer[4][10]. Synthetic analogs like PHAD are manufactured under cGMP guidelines for clinical use[6].
- Brand names
- PHAD3D-PHAD3D(6A)-PHAD
- Other names
- Monophosphoryl Lipid A Free Acid
02
Targets
TLR4 (Toll-like receptor 4)
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