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monosodium inosinate
- Development stage
- Unknown
- Lead developer
- Okayama University Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Monosodium inosinate is a sodium salt of inosine monophosphate (IMP), a naturally occurring nucleotide. It is widely known as a food additive used as a flavor enhancer, particularly for providing the umami taste. In a clinical context, it is being investigated for its potential to treat xerostomia (dry mouth) by stimulating salivary flow. Its mechanism of action involves the activation of umami taste receptors, specifically the T1R1/T1R3 heterodimer, which triggers a gustatory-salivary reflex. Research conducted by Okayama University Hospital has explored its efficacy in healthy adults to evaluate changes in salivation flow following intraoral administration.
- Other names
- IMPsodium inosinateinosine 5'-monophosphate monosodium salt
02
Targets
TAS1R1 (Taste receptor type 1 member 1)T1R1/T1R3 (Taste receptor type 1 member 1 and Taste receptor type 1 member 3 heterodimer)
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