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monovalent sabin inactivated poliovirus vaccine
- Development stage
- Unknown
- Lead developer
- Intravacc
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular, Subcutaneous
01
Overview
**Monovalent Sabin inactivated poliovirus vaccine (sIPV)** is an injectable vaccine containing inactivated poliovirus derived from the attenuated Sabin strains, formulated to target a single poliovirus serotype (type 1, 2, or 3). It induces humoral immunity through systemic IgG antibodies that prevent viremia and protect against paralytic polio, offering a safer production profile with lower biocontainment requirements than wild-type IPV. Primarily used in polio eradication efforts, it provides robust protection (≥99% after three doses) without the risk of vaccine-derived polio associated with live oral vaccines, and has been standardized by WHO with units like Sabin D-Antigen Units (SDU).[1][2][5]
- Other names
- sIPVsabin IPV
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