moperone

Moperone is a typical antipsychotic of the butyrophenone class, formerly marketed under the brand name Luvatren (now discontinued) in Japan for the treatment of schizophrenia. It acts primarily as an antagonist at dopamine D2 and D3 receptors, with additional antagonistic activity at serotonin 5-HT2A receptors and high affinity for sigma receptors. Moperone also exhibits antagonism at dopamine D4 receptors, inverse agonist activity at histamine H1 receptors, and weak inhibition of acetylcholinesterase. Its primary clinical use was in managing schizophrenia and other psychotic disorders; it has also been investigated or used off-label for conditions such as epilepsy and alcohol withdrawal syndrome[1][5][6].

Brand names

Luvatren

Other names

Moprin