Drug intelligence / Profile preview

morinda citrifolia

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Morinda citrifolia, commonly known as noni or Indian mulberry, is an evergreen tree native to the Pacific Islands, Southeast Asia, Australia, and India. Traditionally used in herbal medicine for a variety of ailments including colds, bacterial infections, fevers, gastrointestinal problems[2][3][4], and more recently promoted as a dietary supplement for immune system health and digestive health[2]. The fruit contains compounds such as anthraquinones (e.g., damnacanthal), lignans[3], essential oils (hexanoic and octanoic acids), and other phytochemicals. Laboratory studies suggest antioxidant[3], immunomodulating[3], antimicrobial[5], antifungal[5], antiviral (notably against Epstein-Barr virus)[3], anti-inflammatory[5], analgesic[5] and antitumor properties; however clinical evidence in humans is limited or lacking for most indications. Noni juice has been studied for potential benefits in reducing LDL oxidation (cardiovascular protection)[3] and postoperative nausea/vomiting reduction in one study[3]. The mechanism of action is not fully established but may involve modulation of immune responses (macrophage activation/nitric oxide production) and antioxidant effects.

Brand names
Tahitian Noni
Other names
noniIndian mulberryhog applecanarywoodmorinda
02

Targets

MAPK6 (Mitogen-activated protein kinase 6)MGLL (Monoacylglycerol lipase)PPARG (Peroxisome proliferator-activated receptor gamma)NO2- (Nitrite)

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