morinda officinalis polysaccharides

Morinda officinalis polysaccharides (MOPs) are bioactive carbohydrate polymers extracted from the roots of *Morinda officinalis* How, a traditional Chinese medicinal plant known as Ba-Ji-Tian. These polysaccharides consist of complex structural forms, including inulin-type fructans and acidic polysaccharides composed of galacturonic acid, arabinose, and galactose. MOPs demonstrate a wide range of pharmacological activities, including anti-osteoporotic, anti-inflammatory, antioxidant, and renoprotective effects. Their mechanism of action involves the modulation of the Gut-Kidney axis, where they reshape gut microbiota communities and activate PPARγ and GPCR signaling pathways to reduce systemic inflammation and renal fibrosis. Additionally, MOPs influence the BMP/Smads and Wnt/β-catenin signaling pathways to promote osteoblast differentiation and bone formation. They are being investigated for the treatment of chronic kidney disease (CKD), osteoporosis, rheumatoid arthritis, depression, and infertility.

Other names

MOPsBa-Ji-Tian polysaccharidesMorinda officinalis How polysaccharidesMI Gel