Drug intelligence / Profile preview

moringa oleifera ethanolic extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Moringa oleifera ethanolic extract is a natural product derived from the seeds of the Moringa oleifera plant. It has demonstrated neuroprotective and antioxidant properties in preclinical studies. In a Parkinson's disease mouse model, oral administration of the extract significantly reduced motor dysfunction and neurodegeneration induced by rotenone. Its mechanism of action is believed to involve enhancing antioxidant capacities, as evidenced by increased levels of reduced glutathione (GSH) and activities of glutathione-s-transferase (GST) and catalase (CAT), while reducing lipid peroxidation (LPO). These effects suggest its potential application in neurodegenerative diseases.

02

Targets

AMY (Pancreatic alpha-amylase)PNLIP (Pancreatic triacylglycerol lipase)

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