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morphine + Exparel
- Development stage
- Unknown
- Lead developer
- Pacira BioSciences
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Infiltration (for Exparel, Postsurgical Local Infiltration), Peripheral Nerve Block (for Exparel), Intravenous (for Morphine), Intramuscular (for Morphine), Subcutaneous (for Morphine), Oral (for Morphine)
01
Overview
A combination of **morphine** and **Exparel** (bupivacaine liposome injectable suspension). Morphine is an opioid analgesic that provides pain relief by acting primarily as an agonist at the mu-opioid receptor, leading to inhibition of pain pathways in the central nervous system. Exparel is a long-acting, non-opioid local anesthetic that delivers bupivacaine via a multivesicular liposome (DepoFoam) system for extended release, providing prolonged local or regional analgesia after surgery. The combination is not a standard fixed-dose product; both drugs may be used together in clinical pain management, though no specific, co-formulated product "morphine + Exparel" is approved.
02
Targets
MOR (Mu opioid receptor)NaV (Voltage-gated sodium channels)
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