Drug intelligence / Profile preview

morphine + Exparel

Development stage
Unknown
Lead developer
Pacira BioSciences
Modality
Nanoparticles → Drug Delivery Systems, Small Molecules
Administration
Infiltration (for Exparel, Postsurgical Local Infiltration), Peripheral Nerve Block (for Exparel), Intravenous (for Morphine), Intramuscular (for Morphine), Subcutaneous (for Morphine), Oral (for Morphine)
01

Overview

A combination of **morphine** and **Exparel** (bupivacaine liposome injectable suspension). Morphine is an opioid analgesic that provides pain relief by acting primarily as an agonist at the mu-opioid receptor, leading to inhibition of pain pathways in the central nervous system. Exparel is a long-acting, non-opioid local anesthetic that delivers bupivacaine via a multivesicular liposome (DepoFoam) system for extended release, providing prolonged local or regional analgesia after surgery. The combination is not a standard fixed-dose product; both drugs may be used together in clinical pain management, though no specific, co-formulated product "morphine + Exparel" is approved.

02

Targets

MOR (Mu opioid receptor)NaV (Voltage-gated sodium channels)

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