morphine + remifentanil

Morphine + remifentanil is a combination of two opioid analgesics used together primarily in anesthesia and perioperative pain management. Morphine is a naturally occurring opioid that acts as an agonist at the mu-opioid receptor, providing potent analgesia and sedation. Remifentanil is a synthetic, ultra-short-acting opioid also acting as a selective mu-opioid receptor agonist, notable for its rapid onset and offset due to metabolism by nonspecific blood and tissue esterases. The combination may be used to enhance intraoperative or postoperative pain control, particularly in settings such as cardiac surgery or intensive care where rapid titration of analgesia is required[4][5]. Both drugs act synergistically on the central nervous system to provide profound analgesia but require careful monitoring due to risks of respiratory depression and other opioid-related adverse effects.

Other names

Remifentanil plus Intrathecal MorphineRITM-IVM regimen