Drug intelligence / Profile preview

morphine-ADER-IMT

Development stage
Unknown
Lead developer
Assertio
Modality
Small Molecules
Administration
Oral
01

Overview

**Morphine-ADER-IMT** is an **abuse-deterrent, extended-release (ER) morphine formulation** produced using a proprietary **injection-molded tablet technology** (Guardian, originally developed by Egalet, now owned by Assertio). This manufacturing process incorporates a polymer matrix, resulting in a tablet with both strong physical and chemical barriers designed to resist tampering, crushing, or extraction. These features help deter abuse by limiting methods commonly used to prepare tablets for snorting or injection. The tablet forms a viscous hydrogel upon contact with liquid, further preventing manipulation for illicit routes of administration. It is clinically indicated for the treatment of **moderate to severe chronic pain** when alternative treatment options are inadequate. The abuse-deterrent properties have been demonstrated to lower the potential for misuse relative to non-abuse-deterrent morphine ER products[1][2][3][4][5][6].

Brand names
Arymo ER
Other names
morphine-ADER-IMTabuse-deterrent, extended-release injection-molded tabletsAD, ER injection-molded tablets
02

Targets

DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)MOR (Mu opioid receptor)

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