Drug intelligence / Profile preview

morus alba flavonoid extract

Development stage
Preclinical
Lead developer
Qiqihar Medical University
Modality
Small Molecules
Administration
Oral
01

Overview

Morus alba flavonoid extract refers to the complex mixture of flavonoids isolated from different parts of the Morus alba (white mulberry) plant, including leaves, fruits, root bark, and cortex. The extract is rich in diverse flavonoids (such as morusin, moracin D, sanggenol L, kuwanon G, quercetin, kaempferol, rutin, isoquercitrin, etc.), known for their broad pharmacological activities. Its mechanisms of action include inhibition of α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), activation of AMP-activated protein kinase (AMPK), inhibition of PI3K/Akt/mTOR and Wnt3a/FOXM1/β-catenin signaling pathways, and modulation of cellular oxidative stress and inflammatory signaling. Morus alba flavonoid extract exhibits antidiabetic, antioxidant, anti-inflammatory, anti-cancer, antihyperlipidemic, and neuroprotective effects. The developer is not a single entity; the product is used as a traditional medicine and dietary supplement, and manufactured or formulated by various companies.

Other names
morus alba white mulberry flavonoid extractmorus alba leaf flavonoid extractmorus alba fruit flavonoid extractwhite mulberry flavonoid extract
02

Targets

Sucrase-IsomaltaseAMPK (Adenosine monophosphate–activated protein kinase)PTPN1 (Protein tyrosine phosphatase 1B)

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