morusinol

**morusinol** is a prenylated flavone, a natural flavonoid compound isolated primarily from the root bark of *Morus alba* (white mulberry) and related Morus species. Chemically, it is closely related to morusin but differs by an extra hydroxyl group and lack of a double bond at a specific position in the molecule[1][2]. Morusinol demonstrates significant **anticancer**, **antiplatelet**, and **anti-thrombotic** activity in preclinical research. Key pharmacological properties include the inhibition of cell proliferation and induction of apoptosis and autophagy in cancer cells such as colorectal cancer (by downregulating SREBF2 and cholesterol biosynthesis pathways[3]), liver cancer (by inducing autophagy and cell cycle arrest as well as suppressing the Raf/MEK/ERK pathway[4]), and melanoma (by promoting DNA damage and CHK1 degradation via the ubiquitin-proteasome pathway[6]). Morusinol also inhibits arterial thrombosis and modulates platelet activation, suggesting potential cardiovascular benefit[7][8][10]. It is researched as a potential candidate for the treatment of various types of cancer and thrombosis-related conditions but has not been developed as an approved pharmaceutical drug.

Other names

oxydihydromorusin2-(2,4-dihydroxyphenyl)-5-hydroxy-3-(3-hydroxy-3-methylbutyl)-8,8-dimethylpyrano[2,3-h]chromen-4-one