Drug intelligence / Profile preview

MOSAIC VLP Pan Coronavirus

Development stage
Preclinical
Lead developer
SpyBiotech
Modality
Split/Subunit Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Cancer Vaccines → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Recombinant Protein Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

MOSAIC VLP Pan Coronavirus is a preclinical-stage vaccine candidate developed by SpyBiotech designed to provide broad protection against multiple coronaviruses, including SARS-CoV-2 and its variants. The vaccine utilizes a mosaic virus-like particle (VLP) platform, where multiple different coronavirus antigens—typically receptor-binding domains (RBDs) from various strains—are simultaneously displayed on the surface of a single VLP. This is achieved using SpyBiotech's proprietary SpyTag/SpyCatcher protein superglue technology, which allows for the stable and high-density attachment of antigens to the VLP scaffold. The goal of this mosaic display is to elicit a diverse and broadly neutralizing antibody response that can recognize conserved epitopes across the coronavirus family, potentially offering protection against future emerging zoonotic threats.

Other names
Mosaic VLP Pan-Coronavirus
02

Targets

RBD (SARS-CoV-2 spike receptor-binding domain)

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