Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
motesanib + FOLFIRI
- Development stage
- Unknown
- Lead developer
- Amgen
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Motesanib + FOLFIRI is a combination regimen consisting of **motesanib**, a small molecule angiogenesis inhibitor, and **FOLFIRI**, a chemotherapy protocol comprising folinic acid (leucovorin), fluorouracil (5-FU), and irinotecan. - **Motesanib** inhibits vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3), platelet-derived growth factor receptor (PDGFR), and stem cell factor receptor (c-Kit), thus blocking tumor angiogenesis. - **FOLFIRI** acts by disrupting DNA synthesis (5-FU), inhibiting DNA replication (irinotecan), and potentiating 5-FU activity (folinic acid). This combination was primarily investigated for **metastatic colorectal cancer (mCRC)** in clinical trials. The regimen was tolerated and showed modest efficacy in both first- and second-line settings.
02
Targets
TS (Thymidylate synthase)KIT (c-KIT proto-oncogene receptor tyrosine kinase)TOP1 (DNA Topoisomerase I)PDGFR (PDGFR family)VEGFR3 (Vascular endothelial growth factor receptor 3)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)
Beyond the preview
Go deeper on motesanib + FOLFIRI.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on motesanib + FOLFIRI.