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Motilitone
- Development stage
- Phase 4
- Lead developer
- Dong-A ST
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
**Motilitone** is an oral Korean prescription botanical prokinetic developed by Dong-A ST for **functional dyspepsia**. It is a standardized 50% ethanol extract of *Corydalis* tuber and *Pharbitis* seed in a 5:1 ratio. Its gastrointestinal effects are attributed principally to dopamine D2 receptor antagonism and serotonin 5-HT1A, 5-HT1B, and 5-HT4 receptor agonism, with reported adrenergic alpha-2 receptor agonism. These combined actions support gastric accommodation, gastric emptying, gastrointestinal transit, and reduction of visceral hypersensitivity. Dong-A ST markets Motilitone tablets containing 30 mg of the combined botanical extract for functional dyspepsia in South Korea. ([donga-st.com](https://www.donga-st.com/en/medicine.php?page=2))
- Brand names
- Motilitone
- Other names
- Corydalis tuber and Pharbitidis semen extract
02
Targets
HTR3A (5-hydroxytryptamine receptor 3A)DRD2 (Dopamine D2 Receptor)HTR4 (5-Hydroxytryptamine receptor 4)
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