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MOTO-CAR HPRT

Development stage: Preclinical
Lead developer: Thunder Biotech
Modality: CAR-Macrophages → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Nanoparticles → Drug Delivery Systems
Administration: Intravenous

Overview

MOTO-CAR HPRT is a preclinical-stage cancer therapeutic developed by Thunder Biotech. It utilizes a nanoparticle-based delivery system to engineer macrophages in vivo with a Chimeric Antigen Receptor (CAR) targeting Hypoxanthine-guanine phosphoribosyltransferase (HPRT). This approach, referred to as MOTO-CAR (Macrophage-Oriented Targeted Oncology CAR), aims to reprogram the tumor microenvironment by directing macrophages to recognize and attack HPRT-expressing cancer cells. Unlike traditional ex vivo CAR therapies, this platform leverages nanoparticle delivery for in situ modification of immune cells, potentially simplifying the manufacturing process and increasing accessibility.

Other names: Nanoparticle MOTO-CAR HPRT

Targets

HPRT1 (Hypoxanthine-guanine phosphoribosyltransferase)

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