Drug intelligence / Profile preview

moxifloxacin + nepafenac + prednisolone acetate

Development stage
Unknown
Lead developer
Harrow
Modality
Small Molecules
Administration
Ophthalmic
01

Overview

This is an **ophthalmic combination drug** containing three active ingredients: - **Moxifloxacin**: a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, leading to interruption of bacterial DNA replication, transcription, and repair. It is used for bacterial infections of the eye[2][4][6]. - **Nepafenac**: a nonsteroidal anti-inflammatory drug (NSAID) that acts as a prodrug, converted in ocular tissues to amfenac, which inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis and hence decreasing inflammation and pain related to ocular surgery or injury. - **Prednisolone acetate**: a synthetic glucocorticoid corticosteroid that suppresses inflammation by inhibiting multiple inflammatory cytokines and decreasing leukocyte infiltration. Used for ocular inflammatory conditions. Together, this combination is used primarily for **the prevention and treatment of infection and inflammation associated with ocular surgery or injury**[1][3][7]. The mechanism combines antibacterial, anti-inflammatory (steroidal), and anti-inflammatory (nonsteroidal) actions.

Other names
moxifloxacin/nepafenac/prednisolone ophthalmicprednisolone ac-moxiflox-nepaf
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)Topo IV (Bacterial Topoisomerase IV)GR (Glucocorticoid receptor)PGHS-1 (Prostaglandin G/H Synthase 1)DNA gyrase

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