moxifloxacin + oleic acid

moxifloxacin + oleic acid refers to a novel chemical conjugate, specifically an amide derivative (often designated as 4m in research literature), where the fluoroquinolone antibiotic moxifloxacin is covalently linked to the fatty acid oleic acid. This conjugation strategy is designed to modify the drug's lipophilicity, potentially enhancing its cellular uptake and altering its biological activity. The conjugate has demonstrated potent cytotoxic effects against prostate cancer cell lines (IC50 < 5 µM) and retains significant antibacterial and antimycobacterial properties. Its primary mechanism of action involves the inhibition of bacterial DNA gyrase and topoisomerase IV, which are essential for DNA replication, though its cytotoxic activity in cancer cells suggests additional or modified pathways of action.

Other names

moxifloxacin-oleic acid conjugatemoxifloxacin oleic acid amideCP-4mCP4mCP 4m