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mPEG-PLGA

Development stage: Preclinical
Modality: Hydrogel Systems → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration: Oral, Intravenous, Inhalation, Intranasal, Intratumoral, Implant, Subcutaneous

Overview

mPEG-PLGA is an amphiphilic diblock copolymer composed of a hydrophilic methoxy poly(ethylene glycol) (mPEG) block and a hydrophobic poly(lactide-co-glycolide) (PLGA) block. It is a widely used material in nanomedicine for the development of various drug delivery systems, including nanoparticles, micelles, polymersomes, and thermosensitive hydrogels. The mPEG component provides a "stealth" layer that reduces protein adsorption and opsonization by the mononuclear phagocyte system, thereby extending the systemic circulation time of the encapsulated therapeutic. The PLGA component is biodegradable and biocompatible, allowing for the encapsulation of hydrophobic drugs and their controlled release through polymer degradation and diffusion. mPEG-PLGA-based systems are being investigated for a broad range of applications, including the delivery of chemotherapeutics for cancer, anti-diabetic agents, antibiotics for multidrug-resistant infections, and gene therapies for neurodegenerative diseases.

Other names: methoxy poly(ethylene glycol)-poly(lactide-co-glycolide)mPEG-b-PLGApoly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

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