Drug intelligence / Profile preview

MPK409

Development stage
Preclinical
Modality
Small Molecules
01

Overview

**MPK409** is an investigational **small-molecule histone deacetylase inhibitor** developed in an academic research setting as a novel epigenetic anticancer agent. Published preclinical work identifies it as one of a series of new HDAC inhibitors with **selectivity toward class I HDACs and HDAC6**, showing antiproliferative and pro-apoptotic activity in models of **germ cell tumors, urothelial carcinoma, renal cell carcinoma, and prostate cancer**, including cisplatin-resistant disease. It appears to remain a **preclinical research compound** rather than a clinically developed pharmaceutical product, with no clear evidence of commercial branding, regulatory approval, or advanced human clinical development.

02

Targets

HDAC1 (Histone Deacetylase 1)HDAC6 (Histone deacetylase 6)

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