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MPN-coated engineered Lactobacillus reuteri
- Development stage
- Preclinical
- Lead developer
- South China University of Technology
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Gene Therapies
- Administration
- Oral
01
Overview
MPN-coated engineered Lactobacillus reuteri is an experimental oral live biotherapeutic product (LBP) developed for the targeted treatment of inflammatory bowel disease (IBD), including ulcerative colitis. The therapeutic platform utilizes the probiotic bacterium *Lactobacillus reuteri* which has been genetically engineered to constitutively express and secrete interleukin-10 (IL-10), a potent anti-inflammatory cytokine. To overcome the challenges of oral delivery, the bacteria are encapsulated within a metal-phenolic network (MPN) coating, typically composed of tannic acid and ferric ions (Fe3+). This protective shell enhances bacterial survival against gastric acid and bile salts while providing intrinsic antioxidant activity by scavenging reactive oxygen species (ROS) at the site of intestinal inflammation. Upon reaching the colon, the engineered bacteria colonize the mucosa and locally deliver IL-10, which modulates the immune response by binding to IL-10 receptors on leukocytes, thereby suppressing pro-inflammatory cytokine production and promoting tissue repair.
- Other names
- Metal-phenolic network-coated engineered Lactobacillus reuteriTannic acid/Fe3+ coated engineered Lactobacillus reuteri
02
Targets
IL10RA (Interleukin-10 Receptor)
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