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Drug intelligence / Profile preview
MPN-coated engineered Lactobacillus reuteri cream
- Development stage
- Phase 2
- Lead developer
- Shenzhen People's Hospital
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Nanoparticles → Drug Delivery Systems
- Administration
- Topical
01
Overview
MPN-coated engineered Lactobacillus reuteri cream is a topical live biotherapeutic product developed by Shenzhen People's Hospital for the treatment of acne. The formulation features *Lactobacillus reuteri* that has been engineered and encapsulated within a metal-phenolic network (MPN) coating composed of zinc sulfate and tannic acid. This specialized coating is designed to enhance the probiotic's survival and colonization on the skin's surface, which is typically a harsh environment for such microbes. By improving bacterial persistence, the therapy aims to modulate the skin's microecology, restore microbial balance, and reduce the inflammatory responses that drive acne progression. It is currently being evaluated in clinical trials for patients with Grade I to III acne.
- Other names
- MPN-coated engineered Lactobacillus reuteriEngineered Lactobacillus Reuteri With a Zinc Sulfate-Tannic Acid MPN Coating
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