MR2-1

MR2-1 is an agonistic mouse monoclonal antibody (clone MR2-1) that targets tumor necrosis factor receptor 2 (TNFR2, also known as CD120b or TNFRSF1B). It is widely utilized as a research-use-only reagent and is being investigated by Universiteit Maastricht in proof-of-principle ex vivo studies. In these studies, MR2-1 is used to stimulate TNFR2 on regulatory T cells (Tregs) isolated from patients with autoimmune or inflammatory diseases—including systemic lupus erythematosus (SLE), ANCA-associated vasculitis, multiple sclerosis (MS), and Crohn's disease—to promote their ex vivo expansion, enhance their suppressive function, and improve their stability and homogeneity for potential autologous cell therapy applications.

Other names

clone MR2-1anti-TNFR2 antibody MR2-1anti-TNFR-2 antibody MR2-1anti-TNFR 2 antibody MR2-1