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mRNA-0184
- Development stage
- Phase 1
- Lead developer
- Moderna
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
mRNA-0184 is a novel, investigational lipid nanoparticle–encapsulated mRNA therapy developed to treat heart failure. It encodes for human relaxin-2 fused to variable light chain kappa (Rel2-vlk), which extends the half-life of the protein. The therapy is designed to stimulate endogenous production of relaxin, a naturally occurring hormone that promotes vasodilation and angiogenesis, potentially improving cardiac function in patients with heart failure. The drug was being evaluated in phase 1 clinical trials for safety and tolerability in adults with chronic heart failure but has since been discontinued for this indication.
- Other names
- Relaxin mRNA therapeutic
02
Targets
RXFP1 (Relaxin family peptide receptor 1)
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