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mRNA-1010.4
- Development stage
- Unknown
- Lead developer
- Moderna
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Vaccines & Immunotherapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intramuscular
01
Overview
mRNA-1010.4 is a specific variation of Moderna's quadrivalent seasonal influenza vaccine candidate, mRNA-1010. It utilizes messenger RNA (mRNA) technology encapsulated in lipid nanoparticles (LNPs) to direct host cells to produce the hemagglutinin (HA) surface proteins of four seasonal influenza strains: A/H1N1, A/H3N2, B/Yamagata, and B/Victoria. The ".4" designation refers to a refined formulation or sequence iteration evaluated in Phase 2 clinical trials (e.g., NCT05827978) aimed at optimizing the immunogenicity profile, particularly for the B strains which have historically shown lower titers in mRNA platforms, and improving the overall safety and reactogenicity profile compared to the original mRNA-1010 construct.
- Other names
- Moderna seasonal influenza vaccine candidate
02
Targets
HA (Hemagglutinin)
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