mRNA-1273.213

mRNA-1273.213 is an investigational multivalent mRNA-based COVID-19 vaccine booster candidate developed by Moderna. It encodes for the spike (S) protein of SARS-CoV-2, specifically designed to target multiple variants of concern, including Beta and Delta, by incorporating 11 mutations found in these variants[7]. The vaccine works by delivering nucleoside-modified messenger RNA encapsulated in lipid nanoparticles, which instructs host cells to produce the viral spike protein and elicit an immune response against SARS-CoV-2[5][7]. Its primary indication is as a booster for COVID-19 prevention, with clinical studies evaluating its immunogenicity and safety compared to other Moderna variant-specific boosters[1][2].