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Drug intelligence / Profile preview
mRNA-1345 + Afluria Quadrivalent
- Development stage
- Unknown
- Lead developer
- Moderna
- Modality
- Vaccines & Immunotherapeutics, mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intramuscular
01
Overview
mRNA-1345 + Afluria Quadrivalent is a coadministration regimen consisting of Moderna's investigational mRNA-based respiratory syncytial virus (RSV) vaccine, mRNA-1345, and Seqirus's licensed quadrivalent inactivated influenza vaccine, Afluria Quadrivalent. mRNA-1345 encodes for the stabilized prefusion F glycoprotein of RSV-A to elicit neutralizing antibodies. Afluria Quadrivalent is a split-virion inactivated vaccine containing antigens from two influenza A subtypes and two influenza B lineages. This regimen is being evaluated in clinical trials to support the simultaneous administration of both vaccines during a single healthcare visit, particularly in older adults, to improve vaccination compliance and provide protection against both seasonal influenza and RSV.
- Other names
- mRNA-1345 + QIVRSV vaccine + influenza vaccine coadministration
02
Targets
HA0 (Influenza B virus hemagglutinin)RSV F (Respiratory syncytial virus fusion protein)HA (Hemagglutinin)
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