mRNA-1403

mRNA-1403 is an investigational trivalent mRNA vaccine developed by Moderna for the prevention of moderate to severe acute gastroenteritis caused by norovirus. The vaccine contains messenger RNA encoding virus-like particles (VLPs) designed to protect against multiple norovirus genotypes. It is administered as a single intramuscular injection and utilizes lipid nanoparticle delivery technology. Norovirus is a highly contagious enteric virus and a leading cause of diarrheal disease worldwide, particularly affecting young children, older adults, and immunocompromised individuals. Clinical trials have shown that mRNA-1403 elicits robust antigen-specific immune responses and has been generally well-tolerated in both younger and older adults[1][2][4][5][6][7].