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mRNA-1608

Development stage: Phase 2
Lead developer: Moderna
Modality: mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Vaccines & Immunotherapeutics
Administration: Intramuscular

Overview

mRNA-1608 is a therapeutic mRNA vaccine candidate developed by Moderna for herpes simplex virus-2 (HSV-2) infections. It aims to induce strong antibody responses with neutralizing and effector functionality combined with cell-mediated immunity. The vaccine is designed to potentially provide cross-protection against HSV-1 as well. In rhesus macaques, the trivalent mRNA-1608 vaccine induced neutralizing antibodies blocking gC2 and gE2 immune evasion and stimulated CD4 T cell responses. As an mRNA vaccine, it leverages Moderna's messenger RNA technology platform, which offers potential advantages in efficacy, speed of development, and production scalability.

Other names: Herpes simplex virus vaccine - Moderna Therapeutics

Targets

HSV-2 gC/gD/gE (Herpes simplex virus type 2 glycoproteins C/D/E)uS8 (Small ribosomal subunit protein uS8)gD (HSV-2 glycoprotein D)

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