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mRNA-based multivalent seasonal influenza vaccine candidates
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
mRNA-based multivalent seasonal influenza vaccine candidates refer to a group of investigational vaccines developed by GSK (formerly in collaboration with CureVac) designed to provide protection against seasonal influenza. These candidates utilize messenger RNA (mRNA) technology encapsulated in lipid nanoparticles (LNPs) to instruct host cells to produce viral hemagglutinin (HA) antigens. By targeting multiple strains of influenza A and B (typically quadrivalent, covering H1N1, H3N2, and two B lineages), these vaccines aim to elicit robust humoral and cellular immune responses. Following a restructuring of their partnership in July 2024, GSK acquired full rights to these candidates, which are currently being evaluated in Phase 2 clinical trials to assess their safety and immunogenicity compared to traditional inactivated influenza vaccines.
- Other names
- GSK mRNA influenza vaccineCureVac/GSK mRNA flu vaccine
02
Targets
HA0 (Influenza B virus hemagglutinin)NeuraminidaseBCR (Hemagglutinin-specific B-cell receptor)T-cell receptor recognizing influenza hemagglutinin peptide-MHC complexes
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