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mRNA-LNP osteoarthritis
- Development stage
- Preclinical
- Lead developer
- SirtLab
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intraarticular
01
Overview
mRNA-LNP osteoarthritis is a preclinical-stage mRNA-based therapeutic being developed by SirtLab for the treatment of osteoarthritis. The therapy utilizes lipid nanoparticle (LNP) delivery technology to deliver messenger RNA (mRNA) encoding Sirtuin 6 (SIRT6) directly to joint tissues. SIRT6 is a key longevity-associated protein that plays a critical role in DNA repair, metabolic regulation, and reducing inflammation. By restoring or elevating SIRT6 expression in aging or damaged chondrocytes, the therapy aims to alleviate cellular senescence, reduce joint inflammation, and promote cartilage regeneration, offering a potential disease-modifying treatment for osteoarthritis.
- Other names
- SIRT6 mRNA-LNP (SirtLab)SirtLab SIRT6 mRNA-LNP
02
Targets
SIRT6 (Sirtuin 6)Innate immune RNA sensors
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