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mRNA seasonal influenza vaccine
- Development stage
- Unknown
- Lead developer
- Moderna
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
mRNA seasonal influenza vaccines are a class of investigational vaccines that utilize messenger RNA technology to induce immunity against seasonal influenza viruses. Unlike traditional egg-based vaccines, these candidates use lipid nanoparticle-encapsulated modified mRNA encoding viral surface glycoproteins, primarily hemagglutinin (HA) and sometimes neuraminidase (NA). This platform allows for rapid development and precise antigenic matching to circulating strains, potentially overcoming the limitations of egg-adapted mutations. Major developers include Moderna (with candidates like mRNA-1010), Pfizer, and Sanofi (in collaboration with Translate Bio).
- Other names
- mRNA flu vaccinemodRNA influenza vaccinemRNA-1010mRNA1010mRNA 1010mRNA-1020mRNA1020mRNA 1020mRNA-1030mRNA1030mRNA 1030
02
Targets
HA (Hemagglutinin)Neuraminidase
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