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mRNA vaccine (HBV large S protein)
- Development stage
- Preclinical
- Lead developer
- Zhejiang University
- Modality
- Vaccines & Immunotherapeutics, mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intramuscular, Subcutaneous
01
Overview
mRNA vaccine (HBV large S protein) refers to therapeutic messenger RNA (mRNA) vaccines designed to express the large surface (S) protein of the hepatitis B virus (HBV) to treat chronic hepatitis B (CHB). A notable preclinical candidate under this category is a codon-optimized mRNA vaccine encoding the full-length HBV large S protein delivered via chitosan nanoemulsions (mRNA@CNE), developed by researchers at Zhejiang University. This vaccine is designed to overcome HBV-induced immune tolerance and stimulate robust cytotoxic memory T-cell responses. In animal models, sequential quadruple therapy combining this mRNA vaccine with entecavir, an antisense oligonucleotide, and interferon-alpha successfully induced a durable functional cure in 50% of carrier mice.
- Other names
- codon-optimized mRNA vaccine (encoding full-length HBV large S protein)mRNA-CNE vaccinemRNA@CNE
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