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MRT5410
- Development stage
- Unknown
- Lead developer
- Sanofi Pasteur
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Inhalation
01
Overview
MRT5410 is an inhaled messenger RNA (mRNA) therapeutic candidate designed for the treatment of cystic fibrosis (CF). Developed by Translate Bio (now part of Sanofi), it utilizes a lipid nanoparticle (LNP) delivery system to transport functional CFTR mRNA directly to the lung epithelial cells. Once inside the cells, the mRNA is translated into functional CFTR protein, which restores chloride ion transport across the cell membrane, addressing the underlying cause of the disease regardless of the patient's specific genetic mutation. MRT5410 is a next-generation candidate following MRT5005, optimized for improved potency and delivery efficiency.
- Other names
- CFTR mRNA therapy
02
Targets
CFTR (Cystic fibrosis transmembrane conductance regulator)
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