mRVD-hemopressin

mRVD-hemopressin is an endogenous **peptide** derived from the alpha chain of hemoglobin with sequence RVDPVNFKLLSH that modulates the endocannabinoid system. It has been reported to act as a **negative allosteric modulator** of cannabinoid receptor 1, a **positive allosteric modulator** of cannabinoid receptor 2, and to block **transient receptor potential vanilloid 1** channels. In preclinical studies, it has shown neuroprotective and cognition-related effects including improvement of memory impairment, reduction of oxidative stress and apoptosis, and protection against amyloid-beta toxicity, supporting exploratory investigation for **Alzheimer's disease** and related disorders involving cholinergic injury and oxidative stress. It appears to be a research-stage endogenous bioactive peptide rather than an approved or clinically established therapeutic product, and no specific commercial developer or manufacturer is clearly established from the provided context.

Other names

mRVD-hemopressinRVD-hemopressinpepcan-12pepcan12pepcan 12mRVD-hemopressin alphaRVDPVNFKLLSH