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mRx-7
- Development stage
- Preclinical
- Lead developer
- MiReven
- Modality
- RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
mRx-7 is a synthetic double-stranded RNA (dsRNA) mimic of microRNA-7 (miR-7) being developed by MiReven as a microRNA-based therapeutic. It functions as a miR-7 replacement therapy designed to restore the levels of this microRNA, which is frequently downregulated in various cancers. The mechanism of action involves the synthetic miR-7 mimic targeting the mRNA of the Epidermal Growth Factor Receptor (EGFR), thereby reducing EGFR protein production and inhibiting EGFR-dependent downstream signaling pathways. mRx-7 is currently in preclinical development, specifically in the IND-enabling stage, for the treatment of several solid tumors including hepatocellular carcinoma (liver cancer), head and neck cancer, metastatic melanoma, and glioblastoma multiforme.
- Other names
- miR-7 mimicmiR7 mimicmiR 7 mimicmiR-7miR7miR 7synthetic dsRNA mimic of miR-7
02
Targets
IGF-1R (Insulin-like growth factor 1 receptor)IRS1 (Insulin receptor substrate 1)
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