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MS-20

Development stage: Unknown
Lead developer: Microbio
Modality: Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
Administration: Oral

Overview

MS-20 is a microbiome-based therapeutic modality developed by Microbio Co Ltd for the treatment of advanced hepatocellular carcinoma (HCC). It functions as a microbiota-modulating agent, designed to manipulate the gut microbiota composition to provide therapeutic benefits. The drug has been evaluated in Phase II clinical trials (such as NCT01055626) to assess its impact on quality of life and survival in patients with advanced HCC. MS-20 is considered a potential strategy for enhancing the efficacy of immunotherapy by optimizing the gut microbiome environment. It is typically administered as a 4 ml solution.

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