MS-II-124

MS-II-124: sourced facts only. name: "In summary, the results support the therapeutic potential of MS-II-124 as a NLRP3 inhibitor and warrant future studies of this compound and its analogs to develop therapeutics for ALI/ARDS." [PMID:38901282]; target: "In summary, the results support the therapeutic potential of MS-II-124 as a NLRP3 inhibitor and warrant future studies of this compound and its analogs to develop therapeutics for ALI/ARDS." [PMID:38901282]; developer: "Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA." [PMID:38901282]; modality: "Our recent studies identified a small molecule, MS-II-124, as a potent NLRP3 inhibitor and potential imaging probe." [PMID:38901282]; stage: "Further studies of MS-II-124 in mouse model of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and NLRP3 knockout mice demonstrated its target engagement, efficacy to suppress inflammatory cytokines and infiltration of immune cells in the lung tissues." [PMID:38901282]