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MSC-AFP
- Development stage
- Unknown
- Lead developer
- Mayo Clinic
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Local
01
Overview
MSC-AFP is an investigational autologous cell-based biologic therapy developed by the Mayo Clinic for the treatment of high, transsphincteric cryptoglandular perianal fistulas. The product consists of approximately 20 million autologous adipose-derived mesenchymal stromal cells (MSCs) that are seeded onto a synthetic biomatrix, specifically the Gore Bio-A Fistula Plug. The treatment protocol involves initial drainage and seton placement, followed six weeks later by the implantation of the MSC-loaded plug into the fistula tract. The MSCs are intended to promote healing and fistula closure through their regenerative and immunomodulatory properties, providing a localized therapeutic effect within the fistula environment.
- Other names
- autologous mesenchymal stromal cell coated fistula plugautologous adipose-derived mesenchymal stromal cellsMSC-loaded Gore Bio-A Fistula Plug
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