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MSC-IL-2 wild-type
- Development stage
- Preclinical
- Lead developer
- Nanjing Drum-Tower Hospital
- Modality
- Cell Therapies, Gene Therapies, Cytokines & Interferons → Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
**MSC-IL-2 wild-type** is an experimental, lentivirally engineered umbilical cord-derived mesenchymal stromal cell product that secretes wild-type murine interleukin-2. It was used as a preclinical comparator to an IL-2 N103R/V106D mutein-expressing MSC construct in collagen-induced arthritis mice. Wild-type IL-2 signals through the interleukin-2 receptor complex and can expand regulatory T cells, CD8-positive T cells, and NK cells; in the reported study, MSC-IL-2 wild-type increased CD8-positive T-cell proportions relative to the Treg-selective mutant construct. ([pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC12797657/))
- Other names
- MSC-IL-2 wild typeMSC-IL2 wild typeMSC-IL 2 wild typewild-type IL-2-expressing mesenchymal stromal cells
02
Targets
IL2RB (IL-2 receptor beta chain)
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