MSC-PLGA

MSC-PLGA is a tissue-engineered bone graft construct consisting of autologous bone marrow-derived mesenchymal stem cells (MSCs) seeded onto a biodegradable poly(lactic-co-glycolic acid) (PLGA) scaffold. This therapeutic approach is primarily investigated for the treatment of aneurysmal bone cysts (ABCs) and other complex bone defects where traditional therapies have failed. The MSCs provide the biological component necessary for osteogenesis, while the PLGA scaffold acts as a temporary three-dimensional structural matrix that supports cell attachment, proliferation, and guided tissue regeneration. As the PLGA scaffold slowly degrades in vivo, it is replaced by newly formed bone tissue. The construct is typically prepared by culturing MSCs in the presence of platelet lysate to enrich the environment with growth factors, thereby enhancing the regenerative potential of the graft.

Other names

autologous bone marrow derived mesenchymal stromal cells on PLGA scaffoldMSC-seeded PLGA scaffoldmesenchymal stem cells on poly(lactic-co-glycolic acid) scaffold