MSC-secreted peptide cocktail

MSC-secreted peptide cocktail is a defined combination of three recombinant human proteins/peptides: annexin A1 (ANXA1), stromal cell-derived factor-1 (SDF-1/CXCL12), and complement component C3a (C3a). Developed by researchers at King's College London, Queen Mary University of London, and the University of Exeter, this cocktail is designed to mimic the beneficial paracrine effects of mesenchymal stromal cells (MSCs) on pancreatic islets. It targets G-protein coupled receptors (GPCRs) on islet beta cells, specifically formyl peptide receptor 2 (FPR2), C-X-C chemokine receptor type 4 (CXCR4), and complement component 3a receptor 1 (C3AR1). Pre-treatment of isolated human islets with this cocktail prior to transplantation has been shown to enhance glucose-stimulated insulin secretion (GSIS), protect against cytokine-induced apoptosis, and improve functional islet survival and glycemic control in vivo in mouse models of type 1 diabetes.

Other names

ANXA1/SDF-1/C3a cocktailMSC-derived GPCR agonist cocktailMSC-derived peptide cocktailMSC-secreted GPCR agonist cocktail